Christian McCaffrey over 59.5 rushing yards
McCaffrey remains the central figure in San Francisco’s offense, and a 59.5-yard rushing threshold is within reach with a solid workload. While the Rams will prioritize slowing him down, San Francisco is unlikely to shy away from feeding its star back. McCaffrey’s ability to generate big plays keeps him a threat even when facing a defense designed to limit him.
Matthew Stafford over 1.5 TD passes
Stafford had an outstanding 2025, leading the league with 46 touchdown passes and accumulating 4,707 passing yards. Entering 2026, he anchors a high-powered offense with a wealth of weapons around him. The current market places Stafford’s touchdown prop at 1.5, with the over carrying a reasonable price near -144, suggesting two touchdown passes are a plausible expectation in a game featuring two potent offenses.
Brock Purdy over 224.5 passing yards
Purdy’s line sits higher at some books, making 224.5 an attractive figure for the over. Although the Rams have upgraded defensively, San Francisco should still generate ample passing opportunities for Purdy to reach this mark, given the team’s offensive volume and pace.
De’Zhaun Stribling over 39.5 receiving yards
Stribling represents the biggest upside play among the quartet. The rookie has drawn considerable buzz entering the season and is expected to play a meaningful role in San Francisco’s passing attack. While the matchup is challenging, reaching 40 receiving yards is attainable if Stribling earns consistent targets and work in the game plan.
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