The Rams sit at 2-3 after a 37-34 overtime loss to the Buffalo Bills on Monday Night Football. Arizona is 1-4 following a 45-21 setback against the Detroit Lions. Despite the Rams’ record, their passing attack remains a significant threat. Matthew Stafford threw for 383 yards and three touchdowns against Buffalo, and Puka Nacua piled up 17 receptions for 138 yards and a touchdown. The bigger question is whether Los Angeles can translate that production into a complete performance.
Special teams have been a problem, prompting a change at kicker. The Rams released Harrison Mevis and signed Blake Grupe after a blocked overtime field goal contributed to the loss to Buffalo.
Rams vs. Cardinals: How to Watch, Start Time
The game kicks off at 4:05 p.m. ET (1:05 p.m. PT) on Sunday, Oct. 18, at SoFi Stadium in Inglewood, California. FOX will broadcast the game, with Kenny Albert on play-by-play, Greg Olsen as analyst, and Pam Oliver reporting from the sideline.
The game will be available on FOX in designated television markets. NFL Sunday Ticket on YouTube and YouTube TV provides out-of-market access, while NFL+ carries live local games on supported mobile devices. The Rams’ local radio broadcast airs on ESPN LA 710 AM.
Injury notes: Cornerback Trent McDuffie is listed as questionable with a groin injury, and safety Kam Curl is questionable with an ankle issue. Arizona will be without rookie running back Jeremiyah Love due to an ankle injury.
Rams vs. Cardinals Odds & Prediction
Week 6 odds include:
– Spread: Rams -12.5
– Moneyline: Rams -800; Cardinals +550
– Total: 51.5 points (Over -112, Under -108)
Kalshi’s matchup market showed the Rams with a substantial margin of victory around kickoff time, while Polymarket’s pricing also favored the Rams. The matchup is viewed as favorable for Los Angeles through the air, with Arizona having allowed a high passing yardage rate and quarterback rating. That could give Stafford opportunities to target Davante Adams and Nacua down the field.
Arizona possesses an offensive playmaker in Trey McBride, who entered the week with 42 receptions and three touchdowns. However, without Love, sustaining balance and keeping the Rams’ offense off the field will be challenging for the Cardinals.
Outlook
Los Angeles should be able to exploit Arizona’s defensive weaknesses and generate enough scoring drives to avoid another late-game letdown.
Prediction: Rams 34, Cardinals 20.
Pick: Rams -12.5; lean Over 51.5.
