Current betting lines place the total at 54.5 and Buffalo as a 4.5-point favorite. Here are four bets to consider for this contest.
Over 54.5 points in the game
The total is steep, but Week 1 shows both offenses can put up points quickly. Detroit lit up the Saints for 31 despite a lull in the second half, and Buffalo dropped 36 against a Houston defense that had been considered sturdy. Josh Allen threw for 334 yards with two passing touchdowns and added two rushing scores. Detroit totaled 469 yards from scrimmage in Week 1, including 378 through the air, while Buffalo accumulated 381 yards vs. Houston.
The last meeting between these clubs produced a combined 90 points, with Buffalo prevailing 48-42 in 2024. With both offenses capable of producing big numbers, another shootout is plausible.
Jahmyr Gibbs to rush for over 79.5 yards
Gibbs highlighted Detroit’s Week 1 performance by carrying 29 times for 156 yards and two rushing TDs, plus 30 receiving yards. That workload shows the kind of volume that makes this prop attainable.
Buffalo’s defense allowed Houston to run for 124 yards in Week 1, and Detroit’s ground game should have ample opportunities to create lanes for Gibbs. Clearing 80 rushing yards on a Thursday night remains very achievable given the recent workload.
DJ Moore to record over 4.5 receptions
Moore made an immediate impact in Buffalo, securing five of eight targets for 100 yards and a touchdown in Week 1. His volume suggests he can sustain a strong target share, especially against a Detroit defense that was exploited through the air by New Orleans.
Moore was among Buffalo’s leaders in targets in Week 1, trailing only Dalton Kincaid in receiving yards, and the over on 4.5 receptions is reachable with five catches.
Jared Goff to throw for over 259.5 passing yards
Goff produced 206 passing yards in Week 1 but connected on two touchdowns and should have more opportunities in a higher-scoring setting. Historically, Goff averaged around 268.5 passing yards per game in 2025, placing him comfortably above the 259.5 line under typical game-flow conditions.
If Detroit’s plans involve more passing to keep pace with Buffalo, Goff’s opportunities to exceed 260 yards increase, especially as the Lions likely won’t jump out to a sizable early lead and may rely more on the passing game as the contest unfolds.
Notes
– All odds are subject to change.
– If you or someone you know is dealing with a gambling problem, seek help through the appropriate channels in your region.
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