As the injury news spread, it was noted that the 49ers will be without the player who made a key plays last season, including a pivotal fumble forced at the 1-yard line in a dramatic win over the Rams. Collins began training camp on the active/PUP list due to a shoulder issue, and the team had hoped he would return in the “second window.” That plan is no longer feasible.
The defensive front took another hit when Sam Okuayinonu broke his foot just before Collins’ injury, resulting in him being placed on injured reserve and sidelined for an extended period. With Collins out, the 49ers are eyeing a rotation at defensive tackle featuring Osa Odighizuwa (if healthy), CJ West, and Gracen Halton. On the edge, the team is expected to deploy Nick Bosa, Keion White, Romello Height, and Khalid Kareem, with potential elevating from the practice squad to fill gaps.
In his rookie season, Collins played 550 snaps and earned a 35.0 PFF grade, tying for the second-lowest among 94 interior defenders who appeared in at least 300 snaps. Despite that mixed track record, he delivered standout moments, including a game-winning play against the Rams at SoFi Stadium last season. There, Collins forced a fumble on running back Kyren Williams and recovered it, halting a potential go-ahead score and becoming a rising name for the defense.
His expected role as a starting nose tackle this season made his absence even more impactful, adding pressure to an already thinner defensive line. The challenge is compounded by the fact that two other key players are working back from injuries. Nick Bosa is anticipated to play in Week 1 after recovering from a torn ACL, while Mykel Williams will begin the season on the reserve/PUP list and miss time. An additional setback came when undrafted defensive tackle James Thompson Jr. did not participate in Tuesday’s practice.
This situation recalls a past challenge the 49ers faced when Drake Jackson suffered a similar patellar tendon tear in November 2023 and did not return to the lineup for some time. Jackson was later waived in May 2025 with a failed physical designation after medical concerns regarding his recovery.
On a brighter note, there was positive news regarding another injury. The team received an encouraging update on tight end George Kittle, who tore his Achilles tendon last January. After eight months of recovery, Kittle returned to practice, and offensive coordinator Klay Kubiak expressed optimism about his progression. He looked fully recovered, taking repetitions at full speed and contributing extensively in practice.
Defensive coordinator Raheem Morris also indicated that Bosa is ready to contribute against the Rams, emphasizing that Bosa’s presence is expected due to his established professionalism and preparation. Morris said he expects Bosa to be active for Week 1, underscoring the player’s readiness and the team’s trust in his process.
As Week 1 approaches, the 49ers face the Rams with a thinner defensive line but hopeful signs on offense, including a return to form for key players. The team will need to rely on depth, strategic rotations, and strong coaching to navigate the early-season injuries and maintain a competitive edge in the upcoming matchup.
