The Melbourne game will be played at the MCG, a venue that seats about 100,000, and the Rams were announced last year as the home team for that contest, part of a multi-year commitment to play in Melbourne.
In total, the NFL will stage a record nine international games next season, including the league’s first games in Paris and Rio de Janeiro.
“The 49ers are a popular franchise within the Australian market, and this rivalry game solidifies what we know is going to be an incredible NFL experience for our fans down under,” said Charlotte Offord, NFL Australia & New Zealand general manager.
Kickoff date and time will be announced later. The Rams have had marketing rights in Australia since the NFL began its international marketing program in 2022.